Can you detoxify chemotherapy drugs?
This is a really important factor to consider when undertaking chemotherapy as a treatment.
Polymorphism in the detoxifying genes can contribute to the differences in the ability of patients to detoxify drugs.
Also, proper functioning of the detoxification mechanisms in the liver is also important for the prevention of cancer and its relapse.
The body’s healthy tissues need to be detoxified after chemotherapy as some of these drugs may acts as carcinogens in their own ways.
Pharmacogenomic studies have been conducted for elucidating the genetic bases for the differences in the patient’s responses to chemotherapy drugs. This genetic information can be used for predicting the safety and efficacy of chemotherapy medications.
This can also offer individualized cancer treatments based on the genetic factors of the person including the inherited variability of the drug target, drug responses, drug toxicities, drug-metabolizing enzymes, and drug transporters.
You can consult a practitioner who can assess your body’s specific ability to deal with the effects of chemotherapy drugs based on your general health, cancer diagnosis and pharmacogenomic results.
Factors that can contribute to the altered drug metabolism and can cause toxicity include:
- Pre-existing liver disease
- Nutritional Status
- Renal function
- GI tract, which is the second most important site for detoxification. Detoxification enzymes like CYP3A4 have been found in higher concentrations at the tips of villi in the intestine indicating the role they play in supporting detoxification.